This error has been reported before but closed as resolved. So creating a new ticket.
After upgrading to 1.643 version of Jenkins and upgrading all plugins to latest, am not able to configure the slave nodes. Any configuration save throws the following error:
javax.servlet.ServletException: java.lang.RuntimeException: Failed to instantiate class hudson.slaves.DumbSlave from {"name":"node007","nodeDescription":"","numExecutors":"8","remoteFS":"/u01/jenkins","labelString":"","mode":"EXCLUSIVE","":["hudson.slaves.JNLPLauncher","hudson.slaves.RetentionStrategy$Always"],"launcher":

{"stapler-class":"hudson.slaves.JNLPLauncher","$class":"hudson.slaves.JNLPLauncher","tunnel":"","vmargs":""}

,"retentionStrategy":

{"stapler-class":"hudson.slaves.RetentionStrategy$Always","$class":"hudson.slaves.RetentionStrategy$Always"}

,"nodeProperties":{"stapler-class-bag":"true","hudson-slaves-EnvironmentVariablesNodeProperty":{"env":{"key":"ANT_HOME","value":"/u01/apache-ant-1.9.1"}},"hudson-tools-ToolLocationNodeProperty":{"locations":[

{"key":"hudson.tasks.Ant$AntInstallation$DescriptorImpl@apache-ant-1.9.1","home":"/u01/apache-ant-1.9.1"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.6","home":"/usr/java/jdk1.6.0_45"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.7","home":"/usr/java/jdk1.7.0_67"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.8","home":"/usr/java/jdk1.8.0_11"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.3","home":"/u01/apache-maven-3.0.3"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.5","home":"/u01/apache-maven-3.0.5"}

]}}}
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:796)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:876)
at org.kohsuke.stapler.MetaClass$13.dispatch(MetaClass.java:411)
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:746)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:876)
at org.kohsuke.stapler.MetaClass$4.doDispatch(MetaClass.java:211)
at org.kohsuke.stapler.NameBasedDispatcher.dispatch(NameBasedDispatcher.java:53)
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:746)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:876)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:649)
at org.kohsuke.stapler.Stapler.service(Stapler.java:238)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:848)
at org.eclipse.jetty.servlet.ServletHolder.handle(ServletHolder.java:686)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1494)
at hudson.util.PluginServletFilter$1.doFilter(PluginServletFilter.java:132)
at hudson.util.PluginServletFilter.doFilter(PluginServletFilter.java:123)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1482)
at hudson.security.csrf.CrumbFilter.doFilter(CrumbFilter.java:49)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1482)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:84)
at hudson.security.UnwrapSecurityExceptionFilter.doFilter(UnwrapSecurityExceptionFilter.java:51)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at jenkins.security.ExceptionTranslationFilter.doFilter(ExceptionTranslationFilter.java:117)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at org.acegisecurity.providers.anonymous.AnonymousProcessingFilter.doFilter(AnonymousProcessingFilter.java:125)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at org.acegisecurity.ui.rememberme.RememberMeProcessingFilter.doFilter(RememberMeProcessingFilter.java:142)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at org.acegisecurity.ui.AbstractProcessingFilter.doFilter(AbstractProcessingFilter.java:271)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at jenkins.security.BasicHeaderProcessor.doFilter(BasicHeaderProcessor.java:93)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at org.acegisecurity.context.HttpSessionContextIntegrationFilter.doFilter(HttpSessionContextIntegrationFilter.java:249)
at hudson.security.HttpSessionContextIntegrationFilter2.doFilter(HttpSessionContextIntegrationFilter2.java:67)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:87)
at hudson.security.ChainedServletFilter.doFilter(ChainedServletFilter.java:76)
at hudson.security.HudsonFilter.doFilter(HudsonFilter.java:171)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1482)
at org.kohsuke.stapler.compression.CompressionFilter.doFilter(CompressionFilter.java:49)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1482)
at hudson.util.CharacterEncodingFilter.doFilter(CharacterEncodingFilter.java:81)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1482)
at org.kohsuke.stapler.DiagnosticThreadNameFilter.doFilter(DiagnosticThreadNameFilter.java:30)
at org.eclipse.jetty.servlet.ServletHandler$CachedChain.doFilter(ServletHandler.java:1474)
at org.eclipse.jetty.servlet.ServletHandler.doHandle(ServletHandler.java:499)
at org.eclipse.jetty.server.handler.ScopedHandler.handle(ScopedHandler.java:137)
at org.eclipse.jetty.security.SecurityHandler.handle(SecurityHandler.java:533)
at org.eclipse.jetty.server.session.SessionHandler.doHandle(SessionHandler.java:231)
at org.eclipse.jetty.server.handler.ContextHandler.doHandle(ContextHandler.java:1086)
at org.eclipse.jetty.servlet.ServletHandler.doScope(ServletHandler.java:428)
at org.eclipse.jetty.server.session.SessionHandler.doScope(SessionHandler.java:193)
at org.eclipse.jetty.server.handler.ContextHandler.doScope(ContextHandler.java:1020)
at org.eclipse.jetty.server.handler.ScopedHandler.handle(ScopedHandler.java:135)
at org.eclipse.jetty.server.handler.HandlerWrapper.handle(HandlerWrapper.java:116)
at org.eclipse.jetty.server.Server.handle(Server.java:370)
at org.eclipse.jetty.server.AbstractHttpConnection.handleRequest(AbstractHttpConnection.java:489)
at org.eclipse.jetty.server.AbstractHttpConnection.content(AbstractHttpConnection.java:960)
at org.eclipse.jetty.server.AbstractHttpConnection$RequestHandler.content(AbstractHttpConnection.java:1021)
at org.eclipse.jetty.http.HttpParser.parseNext(HttpParser.java:865)
at org.eclipse.jetty.http.HttpParser.parseAvailable(HttpParser.java:240)
at org.eclipse.jetty.server.AsyncHttpConnection.handle(AsyncHttpConnection.java:82)
at org.eclipse.jetty.io.nio.SslConnection.handle(SslConnection.java:196)
at org.eclipse.jetty.io.nio.SelectChannelEndPoint.handle(SelectChannelEndPoint.java:668)
at org.eclipse.jetty.io.nio.SelectChannelEndPoint$1.run(SelectChannelEndPoint.java:52)
at winstone.BoundedExecutorService$1.run(BoundedExecutorService.java:77)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1145)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:615)
at java.lang.Thread.run(Thread.java:745)
Caused by: java.lang.RuntimeException: Failed to instantiate class hudson.slaves.DumbSlave from {"name":"node007","nodeDescription":"","numExecutors":"8","remoteFS":"/u01/jenkins","labelString":"","mode":"EXCLUSIVE","":["hudson.slaves.JNLPLauncher","hudson.slaves.RetentionStrategy$Always"],"launcher":

{"stapler-class":"hudson.slaves.JNLPLauncher","$class":"hudson.slaves.JNLPLauncher","tunnel":"","vmargs":""}

,"retentionStrategy":

{"stapler-class":"hudson.slaves.RetentionStrategy$Always","$class":"hudson.slaves.RetentionStrategy$Always"}

,"nodeProperties":{"stapler-class-bag":"true","hudson-slaves-EnvironmentVariablesNodeProperty":{"env":{"key":"ANT_HOME","value":"/u01/apache-ant-1.9.1"}},"hudson-tools-ToolLocationNodeProperty":{"locations":[

{"key":"hudson.tasks.Ant$AntInstallation$DescriptorImpl@apache-ant-1.9.1","home":"/u01/apache-ant-1.9.1"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.6","home":"/usr/java/jdk1.6.0_45"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.7","home":"/usr/java/jdk1.7.0_67"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.8","home":"/usr/java/jdk1.8.0_11"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.3","home":"/u01/apache-maven-3.0.3"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.5","home":"/u01/apache-maven-3.0.5"}

]}}}
at hudson.model.Descriptor.newInstance(Descriptor.java:600)
at hudson.model.Node.reconfigure(Node.java:495)
at hudson.model.Computer.doConfigSubmit(Computer.java:1394)
at sun.reflect.NativeMethodAccessorImpl.invoke0(Native Method)
at sun.reflect.NativeMethodAccessorImpl.invoke(NativeMethodAccessorImpl.java:57)
at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.lang.reflect.Method.invoke(Method.java:606)
at org.kohsuke.stapler.Function$InstanceFunction.invoke(Function.java:298)
at org.kohsuke.stapler.interceptor.RequirePOST$Processor.invoke(RequirePOST.java:46)
at org.kohsuke.stapler.Function$InterceptedFunction.invoke(Function.java:399)
at org.kohsuke.stapler.Function.bindAndInvoke(Function.java:161)
at org.kohsuke.stapler.Function.bindAndInvokeAndServeResponse(Function.java:96)
at org.kohsuke.stapler.MetaClass$1.doDispatch(MetaClass.java:121)
at org.kohsuke.stapler.NameBasedDispatcher.dispatch(NameBasedDispatcher.java:53)
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:746)
... 67 more
Caused by: java.lang.IllegalArgumentException: Failed to instantiate class hudson.slaves.DumbSlave from {"name":"node007","nodeDescription":"","numExecutors":"8","remoteFS":"/u01/jenkins","labelString":"","mode":"EXCLUSIVE","":["hudson.slaves.JNLPLauncher","hudson.slaves.RetentionStrategy$Always"],"launcher":

{"stapler-class":"hudson.slaves.JNLPLauncher","$class":"hudson.slaves.JNLPLauncher","tunnel":"","vmargs":""}

,"retentionStrategy":

{"stapler-class":"hudson.slaves.RetentionStrategy$Always","$class":"hudson.slaves.RetentionStrategy$Always"}

,"nodeProperties":{"stapler-class-bag":"true","hudson-slaves-EnvironmentVariablesNodeProperty":{"env":{"key":"ANT_HOME","value":"/u01/apache-ant-1.9.1"}},"hudson-tools-ToolLocationNodeProperty":{"locations":[

{"key":"hudson.tasks.Ant$AntInstallation$DescriptorImpl@apache-ant-1.9.1","home":"/u01/apache-ant-1.9.1"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.6","home":"/usr/java/jdk1.6.0_45"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.7","home":"/usr/java/jdk1.7.0_67"}

,

{"key":"hudson.model.JDK$DescriptorImpl@Java 1.8","home":"/usr/java/jdk1.8.0_11"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.3","home":"/u01/apache-maven-3.0.3"}

,

{"key":"hudson.tasks.Maven$MavenInstallation$DescriptorImpl@apache-maven-3.0.5","home":"/u01/apache-maven-3.0.5"}

]}}}
at org.kohsuke.stapler.RequestImpl$TypePair.convertJSON(RequestImpl.java:602)
at org.kohsuke.stapler.RequestImpl.bindJSON(RequestImpl.java:404)
at org.kohsuke.stapler.RequestImpl.bindJSON(RequestImpl.java:400)
at hudson.model.Descriptor.newInstance(Descriptor.java:588)
... 81 more
Caused by: java.lang.IllegalArgumentException: java.io.IOException: Failed to create a temporary file in /var/lib/jenkins/nodes/node007
at org.kohsuke.stapler.RequestImpl.invokeConstructor(RequestImpl.java:466)
at org.kohsuke.stapler.RequestImpl.instantiate(RequestImpl.java:703)
at org.kohsuke.stapler.RequestImpl.access$200(RequestImpl.java:81)
at org.kohsuke.stapler.RequestImpl$TypePair.convertJSON(RequestImpl.java:600)
... 84 more
Caused by: java.io.IOException: Failed to create a temporary file in /var/lib/jenkins/nodes/tapljs207
at hudson.util.AtomicFileWriter.<init>(AtomicFileWriter.java:68)
at hudson.util.AtomicFileWriter.<init>(AtomicFileWriter.java:55)
at hudson.XmlFile.write(XmlFile.java:175)
at jenkins.model.Nodes.save(Nodes.java:245)
at hudson.util.PersistedList.onModified(PersistedList.java:173)
at hudson.util.PersistedList.replaceBy(PersistedList.java:85)
at hudson.model.Slave.<init>(Slave.java:172)
at hudson.model.Slave.<init>(Slave.java:148)
at hudson.slaves.DumbSlave.<init>(DumbSlave.java:54)
at sun.reflect.NativeConstructorAccessorImpl.newInstance0(Native Method)
at sun.reflect.NativeConstructorAccessorImpl.newInstance(NativeConstructorAccessorImpl.java:57)
at sun.reflect.DelegatingConstructorAccessorImpl.newInstance(DelegatingConstructorAccessorImpl.java:45)
at java.lang.reflect.Constructor.newInstance(Constructor.java:526)
at org.kohsuke.stapler.RequestImpl.invokeConstructor(RequestImpl.java:451)
... 87 more
Caused by: java.io.IOException: Permission denied
at java.io.UnixFileSystem.createFileExclusively(Native Method)
at java.io.File.createNewFile(File.java:1006)
at java.io.File.createTempFile(File.java:1989)
at hudson.util.AtomicFileWriter.<init>(AtomicFileWriter.java:66)
... 100 more