I first got this error after an upgrade, but then tried a clean install an still get the same.
When clicking on Manage Jenkins > Manage Nodes, redirects to http://SERVER/jenkins/computer a I get the following error:

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Status Code: 500

Exception: java.lang.NoClassDefFoundError: hudson.model.ComputerSet (initialization failure)
Stacktrace:
javax.servlet.ServletException: java.lang.NoClassDefFoundError: hudson.model.ComputerSet (initialization failure)
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:719)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:770)
at org.kohsuke.stapler.Stapler.invoke(Stapler.java:583)
at org.kohsuke.stapler.Stapler.service(Stapler.java:214)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:717)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:290)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at hudson.util.PluginServletFilter$1.doFilter(PluginServletFilter.java:95)
at hudson.util.PluginServletFilter.doFilter(PluginServletFilter.java:87)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at hudson.security.csrf.CrumbFilter.doFilter(CrumbFilter.java:48)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at hudson.security.ChainedServletFilter$1.doFilter(ChainedServletFilter.java:84)
at hudson.security.ChainedServletFilter.doFilter(ChainedServletFilter.java:76)
at hudson.security.HudsonFilter.doFilter(HudsonFilter.java:164)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at org.kohsuke.stapler.compression.CompressionFilter.doFilter(CompressionFilter.java:50)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at hudson.util.CharacterEncodingFilter.doFilter(CharacterEncodingFilter.java:81)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at org.jboss.web.tomcat.filters.ReplyHeaderFilter.doFilter(ReplyHeaderFilter.java:96)
at org.apache.catalina.core.ApplicationFilterChain.internalDoFilter(ApplicationFilterChain.java:235)
at org.apache.catalina.core.ApplicationFilterChain.doFilter(ApplicationFilterChain.java:206)
at org.apache.catalina.core.StandardWrapperValve.invoke(StandardWrapperValve.java:230)
at org.apache.catalina.core.StandardContextValve.invoke(StandardContextValve.java:173)
at org.jboss.web.tomcat.security.SecurityAssociationValve.invoke(SecurityAssociationValve.java:182)
at org.apache.catalina.authenticator.AuthenticatorBase.invoke(AuthenticatorBase.java:433)
at org.jboss.web.tomcat.security.JaccContextValve.invoke(JaccContextValve.java:84)
at org.apache.catalina.core.StandardHostValve.invoke(StandardHostValve.java:128)
at org.apache.catalina.valves.ErrorReportValve.invoke(ErrorReportValve.java:104)
at org.jboss.web.tomcat.service.jca.CachedConnectionValve.invoke(CachedConnectionValve.java:157)
at com.epidataconsulting.osde.valve.CookieValve.invoke(CookieValve.java:52)
at org.apache.catalina.core.StandardEngineValve.invoke(StandardEngineValve.java:109)
at org.apache.catalina.connector.CoyoteAdapter.service(CoyoteAdapter.java:241)
at org.apache.coyote.http11.Http11Processor.process(Http11Processor.java:844)
at org.apache.coyote.http11.Http11Protocol$Http11ConnectionHandler.process(Http11Protocol.java:583)
at org.apache.tomcat.util.net.JIoEndpoint$Worker.run(JIoEndpoint.java:447)
at java.lang.Thread.run(Thread.java:736)
Caused by: java.lang.NoClassDefFoundError: hudson.model.ComputerSet (initialization failure)
at java.lang.J9VMInternals.initialize(J9VMInternals.java:140)
at jenkins.model.Jenkins.getComputer(Jenkins.java:1102)
at sun.reflect.NativeMethodAccessorImpl.invoke0(Native Method)
at sun.reflect.NativeMethodAccessorImpl.invoke(NativeMethodAccessorImpl.java:48)
at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:25)
at java.lang.reflect.Method.invoke(Method.java:600)
at org.kohsuke.stapler.Function$InstanceFunction.invoke(Function.java:288)
at org.kohsuke.stapler.MetaClass$4.doDispatch(MetaClass.java:203)
at org.kohsuke.stapler.NameBasedDispatcher.dispatch(NameBasedDispatcher.java:53)
at org.kohsuke.stapler.Stapler.tryInvoke(Stapler.java:677)
... 42 more

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Please let me know if you need more information. Thank you in advance.